Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-l-galactose mutase.

Abstract

Galactose, a monosaccharide capable of assuming two possible configurational isomers (d-/l-), can exist as a six-membered ring, galactopyranose (Galp), or as a five-membered ring, galactofuranose (Galf). UDP-galactopyranose mutase (UGM) mediates the conversion of pyranose to furanose thereby providing a precursor for d-Galf Moreover, UGM is critical to the… (More)
DOI: 10.1073/pnas.1620191114

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Cite this paper

@article{Zhu2017DecipheringTS, title={Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-l-galactose mutase.}, author={Qinghua Zhu and Qi Chen and Yongxiang Song and Hongbo Huang and Jun Li and Junying Ma and Qinglian Li and Jianhua Ju}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2017}, volume={114 19}, pages={4948-4953} }