Deciphering the splicing code

@article{Barash2010DecipheringTS,
  title={Deciphering the splicing code},
  author={Yoseph Barash and John A. Calarco and Weijun Gao and Qun Pan and Xinchen Wang and Ofer Shai and Benjamin J. Blencowe and Brendan J. Frey},
  journal={Nature},
  year={2010},
  volume={465},
  pages={53-59}
}
Alternative splicing has a crucial role in the generation of biological complexity, and its misregulation is often involved in human disease. Here we describe the assembly of a ‘splicing code’, which uses combinations of hundreds of RNA features to predict tissue-dependent changes in alternative splicing for thousands of exons. The code determines new classes of splicing patterns, identifies distinct regulatory programs in different tissues, and identifies mutation-verified regulatory sequences… 
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