Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases.

@article{Strasser2011DecipheringTR,
  title={Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases.},
  author={Andreas Strasser and Suzanne Cory and Jerry M. Adams},
  journal={The EMBO journal},
  year={2011},
  volume={30 18},
  pages={3667-83}
}
Apoptosis, the major form of programmed cell death in metazoan organisms, plays critical roles in normal development, tissue homeostasis and immunity, and its disturbed regulation contributes to many pathological states, including cancer, autoimmunity, infection and degenerative disorders. In vertebrates, it can be triggered either by engagement of 'death receptors' of the tumour necrosis factor receptor family on the cell surface or by diverse intracellular signals that act upon the Bcl-2… CONTINUE READING
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