Deciphering the role of endogenous opioids in high-frequency TENS using low and high doses of naloxone.

Abstract

Previous human studies have shown that the analgesic effect of high-frequency TENS could not be reversed by low doses of naloxone. The aim of the present study was to reinvestigate the possible contribution of opioid receptors to high-frequency TENS analgesia by using low (0.02 mg/kg) and high (0.14 mg/kg) doses of naloxone. Naloxone (high and low doses… (More)
DOI: 10.1016/j.pain.2010.07.012

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