Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes.

@article{Paepe2012DecipheringTR,
  title={Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes.},
  author={Diane Cala-De Paepe and Emilie Layre and Ga{\"e}lle Giacometti and Luis F Garcia-Alles and Lucia Mori and Daniel Hanau and Gennaro De Libero and Henri de la Salle and Germain Puzo and Martine Gilleron},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 37},
  pages={
          31494-502
        }
}
  • Diane Cala-De Paepe, Emilie Layre, +7 authors Martine Gilleron
  • Published in
    The Journal of biological…
    2012
  • Biology, Medicine
  • Lipids are important antigens that induce T cell-mediated specific immune responses. They are presented to T lymphocytes by a specific class of MHC-I like proteins, termed CD1. The majority of the described CD1-presented mycobacterial antigens are presented by the CD1b isoform. We previously demonstrated that the stimulation of CD1b-restricted T cells by the hexamannosylated phosphatidyl-myo-inositol (PIM(6)), a family of mycobacterial antigens, requires a prior partial digestion of the antigen… CONTINUE READING

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