Deciphering the nuclear bile acid receptor FXR paradigm

  title={Deciphering the nuclear bile acid receptor FXR paradigm},
  author={Salvatore Modica and Raffaella Maria Gadaleta and Antonio Moschetta},
  booktitle={Nuclear receptor signaling},
Originally called retinoid X receptor interacting protein 14 (RIP14), the farnesoid X receptor (FXR) was renamed after the ability of its rat form to bind supra-physiological concentrations of farnesol. In 1999 FXR was de-orphanized since primary bile acids were identified as natural ligands. Strongly expressed in the liver and intestine, FXR has been shown to be the master transcriptional regulator of several entero-hepatic metabolic pathways with relevance to the pathophysiology of conditions… CONTINUE READING
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