Deciphering the nuclear bile acid receptor FXR paradigm

@inproceedings{Modica2010DecipheringTN,
  title={Deciphering the nuclear bile acid receptor FXR paradigm},
  author={Salvatore Modica and Raffaella Maria Gadaleta and Antonio Moschetta},
  booktitle={Nuclear receptor signaling},
  year={2010}
}
Originally called retinoid X receptor interacting protein 14 (RIP14), the farnesoid X receptor (FXR) was renamed after the ability of its rat form to bind supra-physiological concentrations of farnesol. In 1999 FXR was de-orphanized since primary bile acids were identified as natural ligands. Strongly expressed in the liver and intestine, FXR has been shown to be the master transcriptional regulator of several entero-hepatic metabolic pathways with relevance to the pathophysiology of conditions… CONTINUE READING
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model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis

  • A. Mennone, C. J. Soroka, +5 authors J. L. Boyer
  • Am J Pathol
  • 2006
Highly Influential
9 Excerpts

diabetes mellitus Drugs

  • K. R. Stayrook, K. S. Bramlett, +5 authors T. P. Burris
  • 2005
Highly Influential
10 Excerpts

SREBPs: activators

  • J. D. Horton, J. L. Goldstein, M. S. Brown
  • 2002
Highly Influential
4 Excerpts

mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids

  • T. Maruyama, Y. Miyamoto, +5 authors K. Tanaka
  • J Lipid Res
  • 2002
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4 Excerpts

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