Deciphering the molecular basis of breast cancer metastasis with mouse models

@article{Vernon2007DecipheringTM,
  title={Deciphering the molecular basis of breast cancer metastasis with mouse models},
  author={Ann E. Vernon and Suzanne J. Bakewell and Lewis A. Chodosh},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2007},
  volume={8},
  pages={199-213}
}
Breast cancer begins as a localized disease, but has the potential to spread to distant sites within the body. This process—known as metastasis—is the leading cause of death from breast cancer. Whether the ability of cancer cells to metastasize is an intrinsic or acquired feature is currently a topic of considerable debate. Nevertheless, the key cellular events required for metastasis are generally accepted. These include invasion of the surrounding stromal tissue, intravasation, evasion of… CONTINUE READING