Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia.

@article{Bishton2011DecipheringTM,
  title={Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia.},
  author={Mark Bishton and Simon James Harrison and Benjamin P. Martin and Nigel Mclaughlin and Chlo{\'e} James and Emma C Josefsson and Katya J. Henley and Benjamin T Kile and H Miles Prince and Ricky W. Johnstone},
  journal={Blood},
  year={2011},
  volume={117 13},
  pages={
          3658-68
        }
}
Histone deacetylase inhibitor (HDACI)-induced thrombocytopenia (TCP) is a major dose-limiting toxicity of this new class of drugs. Using preclinical models to study the molecular and biologic events that underpin this effect of HDACI, we found that C57BL/6 mice treated with both the HDAC1/2-selective HDACI romidepsin and the pan-HDACI panobinostat developed significant TCP. HDACI-induced TCP was not due to myelosuppression or reduced platelet lifespan, but to decreased platelet release from… CONTINUE READING
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