Deciphering the impact of somatic mutations in exon 20 and exon 9 of PIK3CA gene in breast tumors among Indian women through molecular dynamics approach.

@article{Sudhakar2016DecipheringTI,
  title={Deciphering the impact of somatic mutations in exon 20 and exon 9 of PIK3CA gene in breast tumors among Indian women through molecular dynamics approach.},
  author={N Morankar Sudhakar and C. George Priya Doss and D Thirumal Kumar and Chiranjib Chakraborty and Kushi Anand and Mavanur Suresh},
  journal={Journal of biomolecular structure & dynamics},
  year={2016},
  volume={34 1},
  pages={
          29-41
        }
}
We examined 25 breast tumor samples for somatic mutations in exon 20 and exon 9 of PIK3CA gene in South Indian population. Genomic DNA was isolated and amplified for PIK3CA gene, followed by direct sequencing of purified polymerase chain reaction products. We identified PI3K3CA mutations in 5 of 25 (20%), including four of the mutations in p.H1047R and one in p.H1047L. Nucleotide base substitution A to G (c.3140A > G) and A to T (c.3140A > T) results in p.H1047R and p.H1047L mutation in exon 20… CONTINUE READING
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