Deciphering the genetic basis of speech and language disorders.

  title={Deciphering the genetic basis of speech and language disorders.},
  author={Simon E. Fisher and Cecilia S. L. Lai and Anthony P. Monaco},
  journal={Annual review of neuroscience},
A significant number of individuals have unexplained difficulties with acquiring normal speech and language, despite adequate intelligence and environmental stimulation. Although developmental disorders of speech and language are heritable, the genetic basis is likely to involve several, possibly many, different risk factors. Investigations of a unique three-generation family showing monogenic inheritance of speech and language deficits led to the isolation of the first such gene on chromosome… 

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Dissection of molecular mechanisms underlying speech and language disorders

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  • 2005
Consideration of findings from multiple levels of analysis demonstrates that FOXP2 cannot be characterized as “the gene for speech,” but rather as one critical piece of a complex puzzle, indicating that anyone expecting simple explanations of etiology or evolution should be prepared for some intriguing surprises.

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Although FOXP2 was initially uncovered in humans, model systems have been invaluable in progressing understanding of the function of this gene and its associated pathways in language-related areas of the brain and ongoing work in animal models promises to yield new insights into the genetic and neural mechanisms underlying human speech and language.

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Molecular windows into speech and language disorders

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Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech

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A forkhead-domain gene is mutated in a severe speech and language disorder

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Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder.

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