Deciphering the fine nucleotide diversity of full HLA class I and class II genes in a well‐documented population from sub‐Saharan Africa

@article{Goeury2018DecipheringTF,
  title={Deciphering the fine nucleotide diversity of full HLA class I and class II genes in a well‐documented population from sub‐Saharan Africa},
  author={Thomas Goeury and Lisa E Creary and L Brunet and Maxime Galan and Marie-Anne Pasquier and Barbara Kervaire and A. Langaney and Jean Marie Tiercy and Marcelo A. Fernandez-Vina and Jos{\'e} Manuel Nunes and Alicia Sanchez‐Mazas},
  journal={Hla},
  year={2018},
  volume={91},
  pages={36 - 51}
}
With the aim to understand how next‐generation sequencing (NGS) improves both our assessment of genetic variation within populations and our knowledge on HLA molecular evolution, we sequenced and analysed 8 HLA loci in a well‐documented population from sub‐Saharan Africa (Mandenka). The results of full‐gene NGS‐MiSeq sequencing compared with those obtained by traditional typing techniques or limited sequencing strategies showed that segregating sites located outside exon 2 are crucial to… 
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