Deciphering the Stepwise Binding Mode of HRG1β to HER3 by Surface Plasmon Resonance and Interaction Map

@inproceedings{Peess2015DecipheringTS,
  title={Deciphering the Stepwise Binding Mode of HRG1β to HER3 by Surface Plasmon Resonance and Interaction Map},
  author={Carmen Peess and Leopold von Proff and Sabine P. Goller and Karl Magnus Andersson and Michael Gerg and Magnus Malmqvist and Birgit Bossenmaier and Michael Schraeml},
  booktitle={PloS one},
  year={2015}
}
For the development of efficient anti-cancer therapeutics against the HER receptor family it is indispensable to understand the mechanistic model of the HER receptor activation upon ligand binding. Due to its high complexity the binding mode of Heregulin 1 beta (HRG1β) with its receptor HER3 is so far not understood. Analysis of the interaction of HRG1β with surface immobilized HER3 extracellular domain by time-resolved Surface Plasmon Resonance (SPR) was so far not interpretable using any… CONTINUE READING

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