Deciphering principles of transcription regulation in eukaryotic genomes

  title={Deciphering principles of transcription regulation in eukaryotic genomes},
  author={Dat H Nguyen and Patrik D'haeseleer},
  journal={Molecular Systems Biology},
  pages={2006.0012 - 2006.0012}
Transcription regulation has been responsible for organismal complexity and diversity in the course of biological evolution and adaptation, and it is determined largely by the context-dependent behavior of cis-regulatory elements (CREs). Therefore, understanding principles underlying CRE behavior in regulating transcription constitutes a fundamental objective of quantitative biology, yet these remain poorly understood. Here we present a deterministic mathematical strategy, the motif expression… CONTINUE READING

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