Deciphering intratumor heterogeneity using cancer genome analysis

  title={Deciphering intratumor heterogeneity using cancer genome analysis},
  author={Daeun Ryu and Je-Gun Joung and Nayoung K. D. Kim and Kyu-Tae Kim and Woong-Yang Park},
  journal={Human Genetics},
Intratumor heterogeneity within individual cancer tissues underlies the numerous phenotypes of cancer. Tumor subclones ultimately affect therapeutic outcomes due to their distinct molecular features. Drug-resistant subclones are present at a low frequency in tissues at the time of biopsy, but can also arise as a result of acquired somatic mutations. A number of different approaches have been utilized to understand the nature of intratumor heterogeneity. Clonal analysis using whole exome or… CONTINUE READING
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