Deciphering function and mechanism of calcium-binding proteins from their evolutionary imprints.

@article{Morgan2006DecipheringFA,
  title={Deciphering function and mechanism of calcium-binding proteins from their evolutionary imprints.},
  author={Reginald O Morgan and Silvia Martin-Almedina and Montserrat Garc{\'i}a and Jorge Jhoncon-Kooyip and Miguel Alberto Zarraga Fernandez},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1763 11},
  pages={
          1238-49
        }
}
Calcium-binding proteins regulate ion metabolism and vital signalling pathways in all living organisms. Our aim is to rationalize the molecular basis of their function by studying their evolution using computational biology techniques. Phylogenetic analysis is of primary importance for classifying cognate orthologs; profile hidden Markov models (HMM) of individual subfamilies discern functionally relevant sites by conservation probability analysis; and 3-dimensional structures display the… CONTINUE READING
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