Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology

@article{Noorbakhsh2009DecipheringCM,
  title={Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology},
  author={Farshid Noorbakhsh and Christopher M. Overall and Christopher Power},
  journal={Trends in Neurosciences},
  year={2009},
  volume={32},
  pages={88-100}
}
Classical biological methods involving analyses of one or several genes have been the mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has become clear that these diseases exhibit complex molecular interactions involving both host genomes and environmental determinants. Systems biology represents an integrated and deeper investigation of interacting biomolecules within cells or organisms. This approach has only recently become feasible as high-throughput… CONTINUE READING

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