Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium.

@article{Bulla2008DecidualEC,
  title={Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium.},
  author={Roberta Bulla and Chiara Agostinis and Fleur Bossi and Luigi Rizzi and Alessandra Debeus and Claudio Tripodo and Oriano Radillo and Francesco de Seta and Berhane Ghebrehiwet and Francesco Tedesco},
  journal={Molecular immunology},
  year={2008},
  volume={45 9},
  pages={
          2629-40
        }
}
This study was prompted by the observation that decidual endothelial cells (DECs), unlike endothelial cells (ECs) of blood vessels in normal skin, kidney glomeruli and brain, express surface-bound C1q in physiologic pregnancy. This finding was unexpected, because deposits of C1q are usually observed in pathologic conditions and are associated with complement activation. In the case of DECs, we failed to detect immunoglobulins and C4 co-localized with C1q on the cell surface. Surprisingly, DECs… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Cross - talk between the complement system and endothelial cells in physiologic conditions and in vascular diseases

  • F. ischetti, F. Tedesco
  • Autoimmunity
  • 2006

C 1 q governs deposition of circulating Z Z ology 45 ( 2008 ) 2629 – 2640 immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment

  • F. edesco, M. Pausa, E. Nardon, M. Introna, A. Mantovani, A. Dobrina
  • J . Exp . Med .
  • 2004

Interaction of C 1 q with the receptor calreticulin requires a conformational change in C 1 q

  • T. tokol, P. O’Donnell, +5 authors T. N. Mayadas
  • Scand . J . Immunol .
  • 2004

Platelet - activating factor and kinin - dependent vascular leakage as a novel functional activity of the soluble terminal complement complex

  • F. ossi, F. Fischetti, +5 authors F. Tedesco
  • J . Immunol .
  • 2004

Similar Papers

Loading similar papers…