Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions.

@article{Wassenaar2015DecellularizedSM,
  title={Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions.},
  author={Jean W Wassenaar and Gerry R. Boss and Karen L Christman},
  journal={Biomaterials},
  year={2015},
  volume={64},
  pages={108-14}
}
Several factors can affect drug absorption after intramuscular (IM) injection: drug solubility, drug transport across cell membranes, and drug metabolism at the injection site. We found that potential interactions between the drug and the extracellular matrix (ECM) at the injection site can also affect the rate of absorption post-injection. Using decellularized skeletal muscle, we developed a simple method to model drug absorption after IM injection, and showed that the nature of the drug-ECM… CONTINUE READING
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