Decellularized peripheral nerve supports Schwann cell transplants and axon growth following spinal cord injury.

@article{Cerqueira2018DecellularizedPN,
  title={Decellularized peripheral nerve supports Schwann cell transplants and axon growth following spinal cord injury.},
  author={Susana R. Cerqueira and Yee-Shuan Lee and Robert C Cornelison and Michaela Wynne Mertz and Rebecca A. Wachs and Christine Elizabeth Schmidt and Mary Bartlett Bunge},
  journal={Biomaterials},
  year={2018},
  volume={177},
  pages={
          176-185
        }
}
Schwann cell (SC) transplantation has been comprehensively studied as a strategy for spinal cord injury (SCI) repair. SCs are neuroprotective and promote axon regeneration and myelination. Nonetheless, substantial SC death occurs post-implantation, which limits therapeutic efficacy. The use of extracellular matrix (ECM)-derived matrices, such as Matrigel, supports transplanted SC survival and axon growth, resulting in improved motor function. Because appropriate matrices are needed for clinical… CONTINUE READING
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