Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells.

@article{Yoshida2012DecellularizationOB,
  title={Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells.},
  author={Ryu Yoshida and Patrick Vavken and Martha Meaney Murray},
  journal={The Knee},
  year={2012},
  volume={19 5},
  pages={
          672-5
        }
}
Rupture of ACL is a common injury. While the current surgical treatments are effective, many patients still suffer from precocious osteoarthritis, and there is an increasing interest in bioengineering approaches to improve ACL repair. Bovine collagen is a material currently in use for tissue engineering of ligaments. The alpha-gal epitopes found on bovine cells are a source of immunogenic stimulus for human cells. In this study, we wished to determine if those epitopes could be removed… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Decellularized tissue and cell-derived extracellular matrices as scaffolds for orthopaedic tissue engineering.

VIEW 10 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts.

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Freeze-thaw cycles enhance decellularization of large tendons.