Decay of ccc-DNA marks persistence of intrahepatic viral DNA synthesis under tenofovir in HIV-HBV co-infected patients.

Abstract

BACKGROUND & AIMS In the presence of highly-potent antivirals, persistence of hepatitis B virus (HBV) is most well-characterized by covalently-closed circular DNA (cccDNA) and total intrahepatic DNA (IH-DNA). We sought to determine how antiviral therapy could affect their levels during human immunodeficiency virus (HIV)-HBV co-infection. METHODS Sixty co… (More)
DOI: 10.1016/j.jhep.2016.05.014

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@article{Boyd2016DecayOC, title={Decay of ccc-DNA marks persistence of intrahepatic viral DNA synthesis under tenofovir in HIV-HBV co-infected patients.}, author={Anders Boyd and Karine Lacombe and Fabien Lavocat and Sarah Maylin and Patrick Miailhes and Caroline Lascoux-Combe and Constance Delaugerre and P. M. Girard and Fabien Zoulim}, journal={Journal of hepatology}, year={2016}, volume={65 4}, pages={683-691} }