Decay acceleration of the complement alternative pathway C3 convertase.

  title={Decay acceleration of the complement alternative pathway C3 convertase.},
  author={Dennis E. Hourcade and Lynne M. Mitchell and M. Edward Medof},
  volume={42 1-3},
An ELISA-based method is described for analyzing the mechanism by which the decay of the alternative pathway C3 convertase is accelerated by C3 regulatory proteins. Using this assay, we show that human decay-accelerating factor (DAF) and factor H are active on mature convertase complexes (C3bBb) but not on their nascent precursor (C3bB). This finding has implications on the mechanisms of action of these two regulators. The complement convertases cleave the serum protein C3, and the resulting… CONTINUE READING

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