Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice.

@article{Leung2009DecayacceleratingFS,
  title={Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice.},
  author={Viola W Y Leung and Sheng Bu Yun and Marina Botto and J. Christian Mason and Talat H. Malik and Wenchao Song and Danielle Paix{\~a}o-Cavalcante and Matthew C Pickering and Joseph J Boyle and Dorian O. Haskard},
  journal={The American journal of pathology},
  year={2009},
  volume={175 4},
  pages={
          1757-67
        }
}
  • Viola W Y Leung, Sheng Bu Yun, +7 authors Dorian O. Haskard
  • Published in
    The American journal of…
    2009
  • Biology, Medicine
  • Decay-accelerating factor (DAF; CD55) is a membrane protein that regulates complement pathway activity at the level of C3. To test the hypothesis that DAF plays an essential role in limiting complement activation in the arterial wall and protecting from atherosclerosis, we crossed DAF gene targeted mice (daf-1(-/-)) with low-density lipoprotein-receptor deficient mice (Ldlr(-/-)). Daf-1(-/-)Ldlr(-/-) mice had more extensive en face Sudan IV staining of the thoracoabdominal aorta than Ldlr… CONTINUE READING

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