Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity.


Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance T-cell responses and autoimmunity via increased expression of specific cytokines, most notably interferon (IFN)-gamma. To determine if Daf1 deficiency can exacerbate IFN-gamma-dependent murine mercury-induced autoimmunity (mHgIA), C57/BL6 Daf1(+/+) and Daf1(-/-) mice were exposed to… (More)
DOI: 10.1111/j.1365-2567.2010.03279.x