Decavanadate modulates gating of TRPM4 cation channels.

  title={Decavanadate modulates gating of TRPM4 cation channels.},
  author={Bernd Nilius and Jean Prenen and A. CecileJ.W. Janssens and Thomas Voets and Guy Droogmans},
  journal={The Journal of physiology},
  volume={560 Pt 3},
We have tested the effects of decavanadate (DV), a compound known to interfere with ATP binding in ATP-dependent transport proteins, on TRPM4, a Ca(2+)-activated, voltage-dependent monovalent cation channel, whose activity is potently blocked by intracellular ATP(4-). Application of micromolar Ca(2+) concentrations to the cytoplasmic side of inside-out patches led to immediate current activation followed by rapid current decay, which can be explained by an at least 30-fold decreased apparent… CONTINUE READING
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