Decavanadate Toxicology and Pharmacological Activities: V10 or V1, Both or None?

  title={Decavanadate Toxicology and Pharmacological Activities: V10 or V1, Both or None?},
  author={Manuel Aureliano},
  booktitle={Oxidative medicine and cellular longevity},
This review covers recent advances in the understanding of decavanadate toxicology and pharmacological applications. Toxicological in vivo studies point out that V10 induces several changes in several oxidative stress parameters, different from the ones observed for vanadate (V1). In in vitro studies with mitochondria, a particularly potent V10 effect, in comparison with V1, was observed in the mitochondrial depolarization (IC50 = 40 nM) and oxygen consumption (99 nM). It is suggested that… CONTINUE READING


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