Decapping of long noncoding RNAs regulates inducible genes.

  title={Decapping of long noncoding RNAs regulates inducible genes.},
  author={Sarah Geisler and Lisa J Lojek and A. M. Fathia Khalil and Kristian E Baker and Jeff Coller},
  journal={Molecular cell},
  volume={45 3},
Decapping represents a critical control point in regulating expression of protein coding genes. Here, we demonstrate that decapping also modulates expression of long noncoding RNAs (lncRNAs). Specifically, levels of >100 lncRNAs in yeast are controlled by decapping and are degraded by a pathway that occurs independent of decapping regulators. We find many lncRNAs degraded by DCP2 are expressed proximal to inducible genes. Of these, we show several genes required for galactose utilization are… CONTINUE READING
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