Dec1 and Dec2 are regulators of the mammalian molecular clock

@article{Honma2002Dec1AD,
  title={Dec1 and Dec2 are regulators of the mammalian molecular clock},
  author={Sato Honma and Takeshi Kawamoto and Yumi Takagi and Katsumi Fujimoto and Fuyuki Sato and Mitsuhide Noshiro and Yukio Kato and Ken-ichi Honma},
  journal={Nature},
  year={2002},
  volume={419},
  pages={841-844}
}
The circadian rhythms in mammals are regulated by a pacemaker located in the suprachiasmatic nucleus of the hypothalamus. Four clock-gene families have been found to be involved in a transcription–translation feedback loop that generates the circadian rhythm at the intracellular level. The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter region. Protein products of Per act together with Cry proteins to inhibit… 
A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.
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Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus
TLDR
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Dec1 and Dec2 Expression is Disrupted in the Suprachiasmatic Nuclei of Clock Mutant Mice
TLDR
DEC1 and DEC2 can inhibit CLOCK:BMAL1 transactivation of the clock gene Per1, suggesting that these transcription factors may help regulate circadian timing, and data point to up-regulation of Dec1 and Dec2 by Clock in vivo.
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TLDR
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Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system.
TLDR
It is shown that transcription of the Dec2 gene is regulated by several clock molecules and a negative-feedback loop, and that the Clock/Bmal heterodimer enhances Dec2 transcription via the CACGTG E-boxes, whereas the induced transcription is suppressed by Dec2, which therefore must contribute to its own rhythmic expression.
Circadian Rhythm: A Functional Connection Between SHP and DEC1 Transcription Factor
TLDR
It is established that DEC1 constitutes the negative loop of the SHP oscillating expression and that the DEC1-SHP pathway is intimately involved in energy homeostasis with profound pathophysiologic significance.
The Transcriptional Repressor STRA13 Regulates a Subset of Peripheral Circadian Outputs*
Central and peripheral mammalian circadian clocks regulate a variety of behavioral and physiological processes through the rhythmic transcription of hundreds of clock-controlled genes. The circadian
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