Corpus ID: 24990678

Debut of a somatostatin analog: octreotide in review.

  title={Debut of a somatostatin analog: octreotide in review.},
  author={L. Zindel},
  journal={Connecticut medicine},
  volume={53 12},
  • L. Zindel
  • Published 1989
  • Medicine
  • Connecticut medicine
Octreotide is a long-acting cyclic octapeptide with pharmacologic actions mimicking those of the natural hormone somatostatin. It can suppress the secretion of serotonin, as well as the gastroenteropancreatic peptides gastrin, vasoactive intestinal peptide (VIP), insulin, glucagon, secretin, motilin, and pancreatic polypeptide. It also suppresses growth hormone and decreases splanchnic blood flow. Octreotide is completely and rapidly absorbed following subcutaneous injection and has an… Expand