Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation.

@article{Gut1984DebrisoquinetypePO,
  title={Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation.},
  author={Jiri Gut and Rodolfo Gasser and Pierre Dayer and Thomas Kronbach and T Catin and Urs A. Meyer},
  journal={FEBS letters},
  year={1984},
  volume={173 2},
  pages={287-90}
}
Indirect evidence suggests that the genetically defective metabolism of drugs such as debrisoquine and bufuralol observed in up to 10% of the population (poor metabolizers) is caused by the absence or functional deficiency of a cytochrome P450 isozyme. Using bufuralol-1'-hydroxylation to carbinol to optimize the procedure, 3 cytochrome P450 isozymes (P450A, P450buf, P450C) were purified to apparent electrophoretic homogeneity from human liver microsomes. P450buf had a specific activity of 20.3… CONTINUE READING

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