Debrisoquine oxidation in a Finnish population: the effect of oral contraceptives on the metabolic ratio.

@article{Kallio1988DebrisoquineOI,
  title={Debrisoquine oxidation in a Finnish population: the effect of oral contraceptives on the metabolic ratio.},
  author={Jaana Kallio and Robert E. Lindberg and Risto K. Huupponen and Esko Iisalo},
  journal={British journal of clinical pharmacology},
  year={1988},
  volume={26 6},
  pages={791-5}
}
1. The debrisoquine hydroxylation phenotype was assessed in 211 healthy subjects of Finnish Caucasian origin. 2. A bimodal distribution was observed in the urinary debrisoquine/4-hydroxydebrisoquin ratio. Eleven subjects (about 5%) were poor metabolizers of debrisoquine, when a ratio of 12.6 was used as the cut-off point. 3. The mean metabolic ratio of 35 extensive metabolizers taking oral contraceptives was slightly lower than that of extensive metabolizers not taking contraceptives. This… CONTINUE READING

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