Debrisoquine hydroxylation in a Polish population

  title={Debrisoquine hydroxylation in a Polish population},
  author={Paweł K Kunicki and Dariusz Sitkiewicz and E. Borowiecka and Andrzej Pawlik and Barbara Gawrońska-Szklarz and Rozalia Sterna and V. Bielicka-Sulzyc and Hideo Matsumoto and Maria Radziwoń-Zaleska},
  journal={European Journal of Clinical Pharmacology},
The genetic polymorphism of drug oxidation mediated by cytochrome P450IID6 (CYP2D6) was determined in 154 Polish volunteers using debrisoquine as the test substance. The results showed a bimodal distribution of the debrisoquine metabolic ratio (MR). Nine persons (5.8%) with MR>12.6 were classified as poor metabolisers (gene frequency 0.242), which is in substantial agreement with the data reported for other Caucasian populations. 

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DNA haplotype dependency of debrisoquine 4 - hydroxylase ( CYP 2 D 6 ) expression among extensive metabolizers

  • C Mura, S Panserat, M Vincent-Viry, MM Galteau, R Krishnamoorthy
  • Hum Genet
  • 1993

Poly - morphism of debrisoquine and mephenytoin hydroxylation among Estonians

  • RA Kiivet, Svensson J-O, L Bertillson, F Sjoqvist
  • Pharmacol Toxico
  • 1993

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