Debrisoquine hydroxylation in a Polish population

@article{Kunicki1995DebrisoquineHI,
  title={Debrisoquine hydroxylation in a Polish population},
  author={Paweł K Kunicki and Dariusz Sitkiewicz and E. Borowiecka and Andrzej Pawlik and Barbara Gawrońska-Szklarz and Rozalia Sterna and V. Bielicka-Sulzyc and Hideo Matsumoto and Maria Radziwoń-Zaleska},
  journal={European Journal of Clinical Pharmacology},
  year={1995},
  volume={47},
  pages={503-505}
}
The genetic polymorphism of drug oxidation mediated by cytochrome P450IID6 (CYP2D6) was determined in 154 Polish volunteers using debrisoquine as the test substance. The results showed a bimodal distribution of the debrisoquine metabolic ratio (MR). Nine persons (5.8%) with MR>12.6 were classified as poor metabolisers (gene frequency 0.242), which is in substantial agreement with the data reported for other Caucasian populations. 

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 19 references

DNA haplotype dependency of debrisoquine 4 - hydroxylase ( CYP 2 D 6 ) expression among extensive metabolizers

  • C Mura, S Panserat, M Vincent-Viry, MM Galteau, R Krishnamoorthy
  • Hum Genet
  • 1993

Poly - morphism of debrisoquine and mephenytoin hydroxylation among Estonians

  • RA Kiivet, Svensson J-O, L Bertillson, F Sjoqvist
  • Pharmacol Toxico
  • 1993

Similar Papers

Loading similar papers…