Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians.

Abstract

The alicyclic and aromatic hydroxylation of debrisoquin was studied in Ghanaians. As in a previously studied Caucasian population, the alicyclic 4-hydroxylation of debrisoquin in Ghanaians was polymorphic. Three phenotypes were observed: homozygous extensive metabolizers (58%), heterozygous extensive metabolizers (36%), and homozygous poor metabolizers (6%). In contrast, British Caucasians are primarily monomorphic extensive metabolizers (92%) and homozygous poor metabolizers comprise 8% of the population. Urinary recovery of the drug and its hydroxylated metabolites was significantly less in the Ghanaian subjects. In both Ghanaian and British populations, aromatic hydroxylation producing 5-, 6-, 7-, and 8-hydroxydebrisoquin was shown to parallel the alicyclic 4-hydroxylation of debrisoquin, and thus to be controlled by the same gene locus. Debrisoquin is advocated as a tool for uncovering polymorphism in drug oxidation and its interethnic variations.

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@article{Woolhouse1979DebrisoquinHP, title={Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians.}, author={N. M. Woolhouse and Benjamin Andoh and Asmaa A. Mahgoub and tAlfred P. Sloan and Jeffrey R Idle and Robert L. Smith}, journal={Clinical pharmacology and therapeutics}, year={1979}, volume={26 5}, pages={584-91} }