Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells

Chwan-Chuen King, S. Ramachandran, +6 authors Maryse Barbier
Published 2011 in Cancer Chemotherapy and Pharmacology

Abstract

To characterize the cellular action mechanism of Debio 0507, we compared the major DNA adducts formed by Debio 0507- and oxaliplatin-treated HCT116 human colon carcinoma cells by a combination of inductively coupled plasma mass spectrometry (ICP-MS) and ultraperformance liquid chromatography mass spectrometry (UPLC-MS/MS). HCT116 cells were treated with… (More)

DOI: 10.1007/s00280-011-1744-3

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Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells

Abstract

Topics

6 Figures and Tables

Cited By

References

Development of an ultraperformance liquid chromatography/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts.

Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles.

Pt NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA

Displacement of the bidentate malonate ligand from (d,l-trans-1,2-diaminocyclohexane)malonatoplatinum(II) by physiologically important compounds in vitro.

Intracellular biotransformation of platinum compounds with the 1,2-diaminocyclohexane carrier ligand in the L1210 cell line.

Mechanism of the reaction between cis-[PtCl2(NH3)2] and DNA in vitro

different nucleotide sequence preferences in vitro and in cells

Towards biomarker-dependent individualized chemotherapy: exploring cell-specific differences in oxaliplatin-DNA adduct distribution using accelerator mass spectrometry.

A study of oxaliplatin-nucleobase interactions using ion trap electrospray mass spectrometry.

LEF-1 recognition of platinated GG sequences within double-stranded DNA. Influence of flanking bases.

Slides referencing similar topics

Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells

Abstract

Topics

6 Figures and Tables

Cited By

References

Development of an ultraperformance liquid chromatography/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts.

Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles.

Pt NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA

Displacement of the bidentate malonate ligand from (d,l-trans-1,2-diaminocyclohexane)malonatoplatinum(II) by physiologically important compounds in vitro.

Intracellular biotransformation of platinum compounds with the 1,2-diaminocyclohexane carrier ligand in the L1210 cell line.

Mechanism of the reaction between cis-[PtCl2(NH3)2] and DNA in vitro

different nucleotide sequence preferences in vitro and in cells

Towards biomarker-dependent individualized chemotherapy: exploring cell-specific differences in oxaliplatin-DNA adduct distribution using accelerator mass spectrometry.

A study of oxaliplatin-nucleobase interactions using ion trap electrospray mass spectrometry.

LEF-1 recognition of platinated GG sequences within double-stranded DNA. Influence of flanking bases.

Similar Papers

Slides referencing similar topics