Debate Surges Over the Origins of Genomic Defects in Cancer

@article{Marx2002DebateSO,
  title={Debate Surges Over the Origins of Genomic Defects in Cancer},
  author={J. Marx},
  journal={Science},
  year={2002},
  volume={297},
  pages={544 - 546}
}
  • J. Marx
  • Published 2002
  • Medicine, Biology
  • Science
Cancer cells are chock-full of mutations and chromosomal abnormalities, but there's no agreement among researchers on how incipient cancer cells accumulate so many changes. Increasingly, the debate is focusing on the role of genomic instability: some kind of inherent defect that makes the cancer cell genome more susceptible than that of normal cells to developing the various abnormalities. Some researchers maintain that genomic instability is needed early on to set cells on the path to cancer… Expand
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