Debate: A subversive view of subsets - a dissident clinician's opinion

@article{Julian2000DebateAS,
  title={Debate: A subversive view of subsets - a dissident clinician's opinion},
  author={Desmond G. Julian},
  journal={Current Controlled Trials in Cardiovascular Medicine},
  year={2000},
  volume={1},
  pages={28 - 30}
}
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients differ widely from one another in their prognosis and response to treatment. Few trials are large enough to demonstrate convincingly these differences in outcome, but often provide suggestive… CONTINUE READING