Deaths Involving the Benzodiazepine Flunitrazepam

  title={Deaths Involving the Benzodiazepine Flunitrazepam},
  author={Olaf H. Drummer and M L Syrjanen and Stephen M. Cordner},
  journal={The American Journal of Forensic Medicine and Pathology},
A study of eight deaths involving the benzodiazepine flunitrazepam was performed to assess the contribution of this drug to the fatalities. Coronial deaths in Victoria in the 2-year period to mid-1991 were selected in which either flunitrazepam or flunitrazepam and ethanol were the principal toxicological findings. All bodies were subject to a full autopsy by forensic pathologists, and a full toxicological examination. No significant pathology was found at autopsy in any case. Very high… 

A study of deaths involving oxycodone.

Nine deaths involving oxycodone were investigated to assess the contribution of this opiate to these fatalities and it is suggested that Oxycodone is at least as toxic as other opiates and will cause deaths if misused.

Sudden death and benzodiazepines.

Relating these deaths to prescription rates in Victoria suggest that flunitrazepam may be inherently more toxic if misused than other benzodiazepines currently available on the Australian market.

Acute Intoxication Caused by Overdose of Flunitrazepam and Triazolam: High Concentration of Metabolites Detected at Autopsy Examination

The cause of death was determined to be acute intoxication from flunitrazepam and triazolam and their metabolites in the victim’s blood and urine.

Abuse liability of flunitrazepam.

Experimental studies of animals and normal human subjects indicate that, although flunitrazepam has high efficacy and is very potent, it is pharmacologically similar to most other benzodiazepines.

Elimination of 7-aminoflunitrazepam and flunitrazepam in urine after a single dose of Rohypnol.

In urine samples collected from ten healthy volunteers, flunitrazepam was detected three days after Rohypnol intake, in three subjects 24 h, and in one subject 5 days later, to determine how long after drug administration 7-aminoflunitsepam can be detected.

Sedative and hypnotic drugs--fatal and non-fatal reference blood concentrations.

A fatal case of poisoning with ethanol and psychotropic drugs with putrefactive changes.

The cause of death was due to the interaction of paroxetine, flunitrazepam, and ethanol, and the effects of putrefactive changes should be considered during forensic toxicological evaluation.

An autopsy case of death by combined use of benzodiazepines and diphenidine.

An autopsy case involving benzodiazepines and diphenidine was presented and death was attributed to combined toxicity due to the influence of multiple drug interactions.

Nitrobenzodiazepines: Postmortem brain and blood reference concentrations.