Death receptors and melanoma resistance to apoptosis

@article{Ivanov2003DeathRA,
  title={Death receptors and melanoma resistance to apoptosis},
  author={Vladimir N. Ivanov and Anindita Bhoumik and Ze'ev A Ronai},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={3152-3161}
}
Impaired ability to undergo programmed cell death in response to a wide range of external stimuli acquires melanomas a selective advantage for progression and metastasis as well as their notorious resistance to therapy. Better understanding of mechanisms that govern apoptosis has enabled identification of diverse routes by which melanomas manage to escape stimuli of apoptosis. Changes at genomic, transcriptional and post-translational levels of G-proteins and protein kinases (Ras, B-Raf) and… CONTINUE READING

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