Death receptors and ligands in cervical carcinogenesis: an immunohistochemical study.

  title={Death receptors and ligands in cervical carcinogenesis: an immunohistochemical study.},
  author={Nathalie Reesink-Peters and Brigitte M T Hougardy and Fiona A J van den Heuvel and K. A. ten Hoor and Harry Hollema and Hendrika M. Boezen and Elisabeth G. E. de Vries and Steven de Jong and Ate G. J. van der Zee},
  journal={Gynecologic oncology},
  volume={96 3},
OBJECTIVE Increasing imbalance between proliferation and apoptosis is important in cervical carcinogenesis. The death ligands FasL and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induce apoptosis by binding to their cognate cell-surface death receptors Fas or death receptor (DR) 4 and DR5. This study aims to examine if changes in death ligand and death receptor expression during different stages of cervical carcinogenesis are related to an imbalance between proliferation and… CONTINUE READING

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The immunohistochemical expression and localization of Fas / FasL and DR4/DR5/TRAIL were assessed in 11 normal cervices , 15 cervical intraepithelial neoplasia ( CIN ) grade I , 15 CIN II , 13 CIN III , and 25 ( microinvasive ) squamous cell cervical cancers .
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