Death receptor ligation triggers membrane scrambling between Golgi and mitochondria

@article{Ouasti2007DeathRL,
  title={Death receptor ligation triggers membrane scrambling between Golgi and mitochondria},
  author={Sihem Ouasti and P. Matarrese and R E Paddon and Roya Khosravi-Far and Maurizio Sorice and Antonella Tinari and Walter Malorni and Mauro Degli Esposti},
  journal={Cell Death and Differentiation},
  year={2007},
  volume={14},
  pages={453-461}
}
Subcellular organelles such as mitochondria, endoplasmic reticulum (ER) and the Golgi complex are involved in the progression of the cell death programme. We report here that soon after ligation of Fas (CD95/Apo1) in type II cells, elements of the Golgi complex intermix with mitochondria. This mixing follows centrifugal dispersal of secretory membranes and reflects a global alteration of membrane traffic. Activation of apical caspases is instrumental for promoting the dispersal of secretory… CONTINUE READING