Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout

@article{Ehlken2014DeathRF,
  title={Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout},
  author={Hanno Ehlken and Santosh Krishna-Subramanian and Laura Ochoa-Callejero and Vangelis Kondylis and N E Nadi and Beate Katharina Straub and Peter Schirmacher and Henning Walczak and George Kollias and Manolis Pasparakis},
  journal={Cell Death and Differentiation},
  year={2014},
  volume={21},
  pages={1721-1732}
}
Hepatocellular carcinoma (HCC) usually develops in the context of chronic hepatitis triggered by viruses or toxic substances causing hepatocyte death, inflammation and compensatory proliferation of liver cells. Death receptors of the TNFR superfamily regulate cell death and inflammation and are implicated in liver disease and cancer. Liver parenchymal cell-specific ablation of NEMO/IKKγ, a subunit of the IκB kinase (IKK) complex that is essential for the activation of canonical NF-κB signalling… CONTINUE READING
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Molecular mechanisms of hepatic apoptosis

  • K. Wang
  • Cell Death Dis 2014;
  • 2014
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