Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.

@article{Chaudhary1997DeathR5,
  title={Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.},
  author={Preet M. Chaudhary and Michael T Eby and Alan Jasmin and A Bookwalter and Joanna Murray and Leroy Hood},
  journal={Immunity},
  year={1997},
  volume={7 6},
  pages={821-30}
}
Death receptor 4 (DR4) is a recently described receptor for the cytotoxic ligand TRAIL that reportedly uses a FADD-independent pathway to induce apoptosis and does not activate the NF-kappaB pathway. We have isolated a new member of the tumor necrosis factor receptor (TNFR) family, designated DR5, which bears a high degree of sequence homology to DR4. However, contrary to the previous reports, both DR4- and DR5-induced apoptosis can be blocked by dominant-negative FADD, and both receptors can… CONTINUE READING
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