Death of CD4+ T cells from lymph nodes during primary SIVmac251 infection predicts the rate of AIDS progression.

@article{Viollet2006DeathOC,
  title={Death of CD4+ T cells from lymph nodes during primary SIVmac251 infection predicts the rate of AIDS progression.},
  author={Laurence Viollet and Val{\'e}rie Monceaux and Fr{\'e}d{\'e}ric Petit and Rapha{\"e}l Ho Tsong Fang and M C Cumont and Bruno Hurtrel and J{\'e}r{\^o}me Estaquier},
  journal={Journal of immunology},
  year={2006},
  volume={177 10},
  pages={6685-94}
}
Immunological and virological events that occur during the earliest stages of SIV infection are now considered to have a major impact on subsequent disease progression. In the present study, we demonstrate a clear correlation between progression to AIDS and the rate of in vitro CD4+ (but not CD8+) T cell death in lymph nodes. The dying CD4+ T cells were effector memory T cells, which are critical for the immune response to pathogens. However, there was no correlation between the rate of the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
26 Citations
69 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 69 references

Similar Papers

Loading similar papers…