Death mechanisms in cultured cells infected by Semliki Forest virus.

  title={Death mechanisms in cultured cells infected by Semliki Forest virus.},
  author={G M Glasgow and Margaret M. McGee and Brian J. Sheahan and Gregory J. Atkins},
  journal={The Journal of general virology},
  volume={78 ( Pt 7)},
We have investigated the induction of cell death in cultured cells by the virulent SFV4 and avirulent A7 strains of Semliki Forest virus (SFV). In BHK cells, death occurred by a typical apoptotic mechanism, as did the death of oligodendrocytes in glial cell cultures. For cerebellar neuron cultures, virus-induced death was due to necrosis. Although the SFV4 and A7 strains did not differ in the mechanism of induction of cell death, the virulent SFV4 strain did multiply to a higher titre in… CONTINUE READING


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