Death in the third dimension: apoptosis regulation and tissue architecture.

  title={Death in the third dimension: apoptosis regulation and tissue architecture.},
  author={Nastaran Zahir and Valerie M. Weaver},
  journal={Current opinion in genetics & development},
  volume={14 1},
Tissue development, homeostasis and tumor pathogenesis all depend upon a complex dialogue between multiple cell types operating within a dynamic three-dimensional (3D) tissue extracellular matrix microenvironment. A major issue is whether the spatial organization of a cell within this 3D tissue microenvironment could modulate cell responsiveness to regulate cell fate decisions such as survival, and if so how. Classic developmental model systems and transgenic animals are instructive but pose… CONTINUE READING

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