Death-from-cancer signatures and stem cell contribution to metastatic cancer.

  title={Death-from-cancer signatures and stem cell contribution to metastatic cancer.},
  author={Gennadi V. Glinsky},
  journal={Cell cycle},
  volume={4 9},
Genome-wide expression profiling studies reveal a transcriptionally distinct sub-type of human solid tumors with a marked propensity toward metastatic dissemination, highly malignant clinical behavior, and poor therapy outcome in cancer patients diagnosed with the early stage carcinomas of various origins. This sub-set of tumors acquires full metastatic potential, including an emergence and seeding of potent metastasis precursor cells, early in tumor progression. Collectively, these data… CONTINUE READING

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