Death-associated protein kinase 3 mediates vascular inflammation and development of hypertension in spontaneously hypertensive rats.

@article{Usui2012DeathassociatedPK,
  title={Death-associated protein kinase 3 mediates vascular inflammation and development of hypertension in spontaneously hypertensive rats.},
  author={Tatsuya Usui and Muneyoshi Okada and Yukio Hara and Hideyuki Yamawaki},
  journal={Hypertension},
  year={2012},
  volume={60 4},
  pages={1031-9}
}
Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-regulated serine/threonine kinase that mediates cell death. Our recent study demonstrated that DAPK3 protein increases in the mesenteric artery from spontaneously hypertensive rats compared with Wistar Kyoto rats. Pathogenesis of hypertension is modulated at least in part by vascular inflammation. We examined whether DAPK3 mediates vascular inflammatory responses and development of hypertension. In rat mesenteric arterial smooth muscle… CONTINUE READING
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