Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.

@article{Lin2002DeathassociatedP4,
  title={Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.},
  author={Yenshou Lin and Andrei Khokhlatchev and Daniel Figeys and Joseph Avruch},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 50},
  pages={
          47991-8001
        }
}
The protein kinase MST1 is proapoptotic when overexpressed in an active form, however, its physiologic regulation and cellular targets are unknown. An overexpressed inactive MST1 mutant associates in COS-7 cells with an endogenous 761-amino acid polypeptide known as "death-associated protein 4" (DAP4). The DAPs are a functionally heterogeneous array of polypeptides previously isolated by Kimchi and colleagues (Kimchi, A. (1998) Biochim. Biophys. Acta 1377, F13-F33 in a screen for elements… CONTINUE READING

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