Death-associated protein 3 (Dap-3) is overexpressed in invasive glioblastoma cells in vivo and in glioma cell lines with induced motility phenotype in vitro.

@article{Mariani2001DeathassociatedP3,
  title={Death-associated protein 3 (Dap-3) is overexpressed in invasive glioblastoma cells in vivo and in glioma cell lines with induced motility phenotype in vitro.},
  author={Luigi Mariani and Christian Beaudry and Wendy S. McDonough and Dominique B. Hoelzinger and Elżbieta Kaczmarek and Francisco Ponce and Stephen W. Coons and Alf Giese and Rolf W. Seiler and Michael E. Berens},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 8},
  pages={2480-9}
}
PURPOSE To discover the genetic determinants of glioma invasion in vivo, we compared the mRNA expression profiles of glioblastoma cells residing at the tumor core versus those at the invasive rim of a human tumor resection. EXPERIMENTAL DESIGN From a single glioblastoma specimen, 20,000 individual cells from each region (core and invasive rim) were collected by laser capture microdissection and analyzed by mRNA differential display. Differential expression of gene candidates was confirmed by… CONTINUE READING