Death after excessive propofol abuse

@article{IwersenBergmann2001DeathAE,
  title={Death after excessive propofol abuse},
  author={S. Iwersen-Bergmann and P. R{\"o}sner and H. C. K{\"u}hnau and M. Junge and Achim Schmoldt},
  journal={International Journal of Legal Medicine},
  year={2001},
  volume={114},
  pages={248-251}
}
Abstract Abuse of the anaesthetic agent propofol (2,6-diisopropylphenol) is rare, but we report a case of a 26-year-old male nurse in which the autopsy showed unspecific signs of intoxication and criminological evidence pointed towards propofol abuse and/or overdose. Intravenously administered propofol is a fast and short-acting narcotic agent, therefore it seemed questionable whether the deceased would have been able to self-administer a lethal overdose before losing consciousness. The blood… 
Evaluation of a fatal propofol intoxication due to self administration.
Lethal self‐administration of propofol and atracurium
TLDR
These cases, in agreement with other reported cases, highlight the concerns related to the misuse of hospital‐based medicines, especially by health‐care professionals, and so, the need for a much more stringent internal control of such drugs.
Deaths from recreational use of propofol in Korea.
Clinical Effects and Lethal and Forensic Aspects of Propofol *
  • R. Levy
  • Medicine
    Journal of forensic sciences
  • 2011
TLDR
Because propofol has the potential for diversion with lethal consequences, the forensic scientist must have a basic understanding of its clinical indications and uses, pharmacologic properties, and detection methods.
Fatal factors related to abuse of propofol (DIPRIVAN)
TLDR
It would be necessary to investigate the factors that caused amplified side-effects in cases of propofol fatalities unrelated to overdose to determine the cause of death in this case.
Determination of chronic abuse of the anaesthetic agents midazolam and propofol as demonstrated by hair analysis
TLDR
Repetitive consumption of the two anaesthetic agents during the last 6 months before the death was demonstrated and self-administration of midazolam and propofol without respiratory assistance and medical control certainly contributed to the death.
Postmortem Propofol Levels: A Case of Residual Detection Long After Administration
TLDR
This article presents a case illustrating that propofol can accumulate in the tissues and may be found up to a week after administration, and implies that postmortem detection does not necessarily confirm administration near the time of death, and further investigation needs to be undertaken.
Suicide by Self‐Administration of a Drug Mixture (Propofol, Midazolam, and Zolpidem) in an Anesthesiologist: The First Case Report in Italy
TLDR
Forensic and toxicological findings suggested that the cause of death was a respiratory depression due to a self‐administration of a rapidly infused lethal drug mixture, verifying the fact that in Italy recreational abuse of anesthetic and sedative agents in health care practitioners is becoming an increasing problem.
Brugada-like EKG pattern and myocardial effects in a chronic propofol abuser
TLDR
Development of the EKG pattern of ST-segment elevation in leads V1–V3 may be the first indicator of electrical instability and high risk for imminent sudden death in patients poisoned with propofol.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 38 REFERENCES
The first fatal 2,6-di-isopropylphenol (propofol) poisoning in Singapore: a case report.
Disposition in male volunteers of a subanaesthetic intravenous dose of an oil in water emulsion of 14C-propofol.
TLDR
An intravenous dose of 14C-propofol administered to six male volunteers was rapidly eliminated with 88% recovered in the urine in 5 days and less than 2% in faeces and a proportion of the dose was cleared slowly, probably due to slow release from less well perfused tissues.
A fatality due to propofol poisoning.
  • O. Drummer
  • Medicine
    Journal of forensic sciences
  • 1992
This report describes a suicide by self-administration of propofol in a 29-year-old female radiographer. This is the first published report of death by overdosage with propofol. Propofol was detected
Propofol. A review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anaesthetic.
TLDR
Comparative studies have shown propofol to be at least as effective as thiopentone, methohexitone or etomidate for anaesthesia during general surgery, and it is clearly an effective addition to the limited range of intravenous anaesthetics.
Fentanyl-related deaths: demographics, circumstances, and toxicology of 112 cases.
TLDR
Although most of the fentanyl victims had a prior history of intravenous drug use, morphine or codeine were not commonly found, which suggests that the victims had little or no opiate tolerance.
A fatal ketamine poisoning.
TLDR
A rapid and effective solid-phase extraction procedure using Bond-Elute* C18 for Ketamine and Nor-Ketamine detection in biological fluids and tissues with a 75% recovery is discussed.
A pharmacokinetically based propofol dosing strategy for sedation of the critically ill, mechanically ventilated pediatric patient.
TLDR
A descending propofol dosing strategy, which maintains the prop ofol concentration constant in the central compartment (V1) while drug accumulates in V2 and V3 to intercompartmental steady-state, is necessary for effective propofolin sedation in the pediatric ICU.
Arousal from propofol
TLDR
Clinical predictors of intraoperative myocardial ischemia in patients with coronary artery disease undergoing non-cardiac surgery and a comparison of different lead systems using computcrised ST segment analysis.
Fentanyl: a review for clinical and analytical toxicologists.
  • A. Poklis
  • Medicine, Biology
    Journal of toxicology. Clinical toxicology
  • 1995
TLDR
This review is intended as a quick reference source for clinical and analytical toxicologists of fentanyl as a popular drug of abuse among health care professionals.
...
1
2
3
4
...